Searchable abstracts of presentations at key conferences in endocrinology

ea0086p94 | Neuroendocrinology and Pituitary | SFEBES2022

Gene-chromatin regulatory circuits driving stemness in the anterior pituitary

Yianni Val , Lodge Emily J. , Willis Thea L. , Kemkem Yasmine , Zamojski Michel , Mendelev Natalia , Sealfon Stuart C. , Ruf-Zamojski Frederique , Andoniadou Cynthia L.

The pituitary gland is a dynamic organ that adapts its cellular architecture throughout life, making it an ideal model for the study of stem cells (SCs), their commitment and differentiation. Sox2-expressing cells are bona fide anterior pituitary stem cells (PSCs), which through genetic lineage tracing have been shown to give rise to all anterior pituitary hormone-producing cells both in the embryo and adult. The YAP/TAZ signalling pathway has been previously...